发明名称 |
METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM |
摘要 |
The disclosure relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and/or the regulation of eyeball size. These drugs are potential candidates for treating myopia and/or keratoconus disease. |
申请公布号 |
US2014073611(A1) |
申请公布日期 |
2014.03.13 |
申请号 |
US201313899297 |
申请日期 |
2013.05.21 |
申请人 |
NATIONAL TAIWAN UNIVERSITY |
发明人 |
WANG I-JONG;HO WEI-TING;CHIANG TING-HSUAN;LIN I-TSEN |
分类号 |
A61K31/65;A61K31/05;A61K31/138;A61K31/164;A61K31/165;A61K31/18;A61K31/185;A61K31/198;A61K31/351;A61K31/353;A61K31/357;A61K31/366;A61K31/381;A61K31/401;A61K31/4045;A61K31/416;A61K31/4166;A61K31/4178;A61K31/4402;A61K31/4439;A61K31/445;A61K31/5377;A61K31/541 |
主分类号 |
A61K31/65 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|