METHOD FOR PRODUCING A POLYGLYCERIN NANOGEL FOR ENCAPSULATION AND RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES

摘要

The invention relates to a method for producing a polyglycerin nanogel, comprising the following steps: mixing an aqueous solution of first polyglycerin macromonomers (1) which are modified with a first reactive group (10), comprising an aqueous solution of second polyglycerin macromonomers (2) which are modified with a second reactive group (20), wherein the first reactive group (10) and the second reactive group (20) can react with one another, forming a chemical bond; transferring the mixture into an organic non-solvent (4); and precipitating a polyglycerin nanogel (6) which consists of first polyglycerin macromonomers (1) and second polyglycerin macromonomers (2) covalently bonded to one another. The invention is characterised in that the organic non-solvent (4) is miscible with water (3) and that the method is carried out without the addition of surfactant substances.