| 发明名称 |
METHOD FOR SELECTIVELY INHIBITING THE ACTIVITY OF ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE |
| 摘要 |
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2. |
| 申请公布号 |
WO2014039138(A1) |
申请公布日期 |
2014.03.13 |
| 申请号 |
WO2013US46990 |
申请日期 |
2013.06.21 |
| 申请人 |
TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
CHANG, TA-YUAN;CHANG, CATHERINE, C.Y.;BRYLEVA, ELENA;MURPHY, STEPHANIE;ROGERS, MAXIMILLIAN, A. |
| 分类号 |
A61P25/28;A61K31/7088;C07H21/02 |
主分类号 |
A61P25/28 |
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