| 摘要 |
PROBLEM TO BE SOLVED: To provide a BMP-7 for use in treating vascular sclerosis.SOLUTION: The present invention relates to prevention and treatment, using a morphogen, of vascular sclerosis, vascular calcification (VC), and neointimal hyperplasia. In one embodiment, the vascular sclerosis accompanies or is induced by CKD. The present invention also relates to compositions and methods for inducing differentiation of vascular smooth muscle cells. In some embodiments, the invention provides a method for treating or preventing vascular sclerosis in a subject, the method comprising the step of administering a morphogen selected from BMP-7, BMP-5, BMP-6, OP-2 (BMP-8), and variants thereof to the subject. |
