发明名称 METHODS FOR INHIBITION OF BNIP3 AND PREVENTION AND TREATMENT OF ISCHEMIA REPERFUSION INJURY BY TETRA-O-METHYL NORDIHYDROGUAIARETIC ACID
摘要 Provided herein are methods for prevention and treatment of ischemia-reperfusion (IR) injury in the cardiac myocytes of a subject, by administration to the subject, a compound of formula I, or a salt, solvate, or stereoisomer thereof, in a sufficient amount either prior to, or during and/or after an ischemic event to mitigate or prevent IR injury to the cardiac tissue. Pharmaceutical compositions including the compound of formula I, or a salt, solvate, or stereoisomer thereof, and/or at least one additional therapeutic agent, are also provided.
申请公布号 WO2014015136(A3) 申请公布日期 2014.03.13
申请号 WO2013US51074 申请日期 2013.07.18
申请人 THE JOHNS HOPKINS UNIVERSITY 发明人 HUANG, RU CHIH;KIMURA, KOTOHIKO
分类号 C07C43/205;A61K31/085 主分类号 C07C43/205
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