发明名称 |
HIV IMMUNE STIMULATING COMPOSITIONS COMPRISING RECOMBINANTLY EXPRESSED PILI ON BACTERIA AND METHODS RELATED THERETO |
摘要 |
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant bacteria are administered in combination with other HIV antigens, nucleic acids encoding HIV antigens, recombinant virus encoding HIV antigens, anti-viral agents and/or adjuvants in an effective amount to elicit a mucosal immune response against HIV. |
申请公布号 |
WO2014039746(A1) |
申请公布日期 |
2014.03.13 |
申请号 |
WO2013US58383 |
申请日期 |
2013.09.06 |
申请人 |
EMORY UNIVERSITY |
发明人 |
AMARA, RAMA RAO;SCOTT, JUNE R.;QUIGLEY, BERNARD;CHAMCHA, VENKATESWARLU |
分类号 |
A61K39/21;C07K14/155;C12N15/49 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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