ANTIFUNGAL AGENTS AND USES THEREOF

摘要

The invention features echinocandin class compounds that can be useful for the treatment of fungal infections. The echinocandin class compounds have been modified such that they can exhibit (i) activity against one or more fungal species or genera; (ii) increased aqueous solubility and/or amphiphilicity; (iii) have an increased therapeutic index; (iv) suitability for topical administration; (v) suitability for intravenous administration; (vi) have an increased volume of distribution; and/or (vii) have an increased elimination half-life.