发明名称 |
CHEMICALLY MODIFIED OLIGONUCLEOTIDES FOR USE IN MODULATING MICRO RNA AND USES THEREOF |
摘要 |
This invention relates generally to chemically modified oligonucleotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides. Also included in the invention are compositions and methods for silencing microRNAs in the central nervous system. |
申请公布号 |
US2014073684(A1) |
申请公布日期 |
2014.03.13 |
申请号 |
US201314011387 |
申请日期 |
2013.08.27 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC.;THE ROCKEFELLER UNIVERSITY |
发明人 |
STOFFEL MARKUS;MANOHARAN MUTHIAH;RAJEEV KALLANTHOTTATHIL G. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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