Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies

摘要

An in vitro assay method is disclosed. This non-cell-based dual function target binding assay is useful for detecting both an IgG target antibody, such as a biologic drug, in a biological sample (e.g., a serum sample) and the presence of neutralizing antibodies (NAb) against the IgG target antibody.