| 发明名称 |
FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF |
| 摘要 |
The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihy-dropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders. |
| 申请公布号 |
EP2485726(B1) |
申请公布日期 |
2014.03.12 |
| 申请号 |
EP20100760348 |
申请日期 |
2010.10.01 |
| 申请人 |
BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
MICHELS, MARTIN;FOLLMANN, MARKUS;VAKALOPOULOS, ALEXANDROS;ZIMMERMANN, KATJA;TEUSCH, NICOLE;LOBELL, MARIO;BIERER, DONALD;ENGEL, KAREN;KISSEL, MARIA |
| 分类号 |
A61K31/416;C07D401/04 |
主分类号 |
A61K31/416 |
| 代理机构 |
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