| 摘要 |
<p>A microneedle and a microneedle array which can support not only a drug but also a stabilizer and a thickener in large quantities and have excellent puncture property. The microneedle is used to administer a drug transdermally and comprises a top section, a shaft section and a base section, wherein
(i) the tip apex angle (±) is 15 to 60°;
(ii) the tip diameter (D 0 ) is 1 to 20 µm;
(iii) the area (A 3 ) of the top surface of the base section is larger than the area (A 2 ) of the bottom surface of the shaft section;
(iv) the following expressions (1) and (2) are satisfied H / D 4 ‰§ 3
(H is the overall height, and D 4 is the diameter of the bottom surface of the base section) ² ‰§ 90 - 0.5 �¢ ±
(² is the angle formed between the side surface of the shaft section and the top surface of the base section, and ± is the tip apex angle.); and
(v) a solid composition containing a drug is fixed to the side surface of the shaft section and the following expression (5) is satisfied. 10 �¢ ° ‰¦ ³ ‰¦ 60 �¢ °
(³ is the angle formed by tangent lines connecting the apex of the top section and the surface of the solid composition fixed to the side surface of the shaft section.)</p> |
