发明名称 |
COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION |
摘要 |
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue. |
申请公布号 |
EP2613776(A4) |
申请公布日期 |
2014.03.12 |
申请号 |
EP20110822537 |
申请日期 |
2011.08.31 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
IWAMOTO, MASAHIRO;PACIFICI, MAURIZIO |
分类号 |
A61K31/19;A61K31/185;A61K31/192;A61P21/00 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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