Predicting capecitabine toxicity

摘要

A method of predicting capecitabine toxicity in a patient includes determining a patient's genotype for one or more genetic variants in one or more genes involved in capecitabine metabolism. The genetic variant may be a single nucleotide polymorphism in the gene encoding MTHFR and/or the gene encoding CDA. The genetic variant may be found at MTHFR 677, and/or at MTHFR 1298, and/or CDA - 92 and/or at CDA -451.