Method for fabrication of highly porous, calcium phosphate bioactive implant material

摘要

The present invention solves the problem of manufacturing bioactive implant material showing particular properties.

In the method according to the invention, the suspension of gelatinous amorphous calcium phosphate synthesized previously by the wet method at Ca/P molar ratio within the range 1.45-1.75 with optional addition of ionic modifiers, preferably CO₃^2-, Mg²⁺, Mn²⁺, is subjected to aging and sedimentation processes, after which it is decanted and concentrated to the precipitate containing 75-82% of water. The filter cake thus obtained is dried at the temperature of 70-100°C until constant mass, then subjected to mechanical working followed by calcination of the semi-final product obtained at 400-1000°C for 1-5 hours which results in a microporous, mono- or two-phase material of unimodal pore size distribution in the range of 0.05-0.5 µm in the form of granules or shaped articles. In order to obtain granules, the filter cake after drying is crushed into fractions of grain sizes within 0.1-2 mm using appropriate sieves and calcined, whereas in order to obtain shaped implant articles the cake after drying is processed appropriately to get the desired shape and calcined.