发明名称 |
Activation of peptide prodrugs by hK2 |
摘要 |
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention. |
申请公布号 |
US8669231(B2) |
申请公布日期 |
2014.03.11 |
申请号 |
US20110987409 |
申请日期 |
2011.01.10 |
申请人 |
DENMEADE SAMUEL R.;ISAACS JOHN TOD;LILJA HANS;GENSPERA, INC. |
发明人 |
DENMEADE SAMUEL R.;ISAACS JOHN TOD;LILJA HANS |
分类号 |
A61P35/00;A61K38/00;A61K38/04;A61K38/08;A61K47/42;A61K47/48;C07K1/00;C07K7/06;C07K14/47 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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