| 摘要 |
Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (-C=O), methyl hydroxyl group (-CH(OH)), methyl ketone or methyl dimethoxy group (-CH(OCH3)2); and wherein while R1 is oxygen (-O-) and R2 is carbonyl group (-C=O) or methyl hydroxyl group (-CH(OH)), a single bond is formed between R1 (-O-) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring. |
