发明名称 |
AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE |
摘要 |
<p>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.</p> |
申请公布号 |
KR20140027974(A) |
申请公布日期 |
2014.03.07 |
申请号 |
KR20137029216 |
申请日期 |
2012.04.05 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER JEAN DAMIEN;MACCORMICK SOMHAIRLE;STORCK PIERRE HENRI;PINDER JOANNE;O'DONNELL MICHAEL EDWARD;KNEGTEL RONALD MARCELLUS ALPHONSUS;YOUNG STEPHEN CLINTON YOUNG;KAY DAVID;REAPER PHILIP MICHAEL;DURRANT STEVEN JOHN;TWIN HEATHER CLARE;DAVIS CHRISTOPHER JOHN |
分类号 |
C07D413/14;A61K31/497;A61P35/00 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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