发明名称 AMINE SALT AND CRYSTALS THEREOF
摘要 Provided is a compound that can serve as a drug for the treatment of underactive bladder, which can be administered orally and poses little risk of side effects. Also provided are crystals that are advantageous as the bulk drug of a pharmaceutical in terms of stability, long-term storage, ease of handling, ease of formulation, and the like. Salts of 2-[(2-{(1R,5R)-2-oxo-5-[(1E,4S)-7,8,8-trifluoro-4-hydroxy-4-methyl-1,7- octadien-1-yl]cyclopentyl}ethyl)thio]-1,3-thiazole-4-carboxylic acid, or a mixture of diastereomers thereof, and 4-piperidinemethanol are extremely chemically stable crystals and therefore permit long-term storage and are very useful as the bulk drug of a pharmaceutical.
申请公布号 WO2014034902(A1) 申请公布日期 2014.03.06
申请号 WO2013JP73442 申请日期 2013.08.30
申请人 ONO PHARMACEUTICAL CO., LTD. 发明人 TANI, KOUSUKE;KINOSHITA, AKIHIRO;HANADA, KEISUKE;ARATANI, YOSHIYUKI;NEKADO, TAKAHIRO;SHIMABUKURO, ATSUSHI
分类号 C07D277/20;A61K31/426;A61K47/40;A61P13/02;A61P13/10;A61P43/00;C07D211/22;C07D277/56;C08B37/16 主分类号 C07D277/20
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