USE OF (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION

摘要

PROBLEM TO BE SOLVED: To provide a method of treating hematologic disorders such as leukemia.SOLUTION: The treatment method comprises administering to a mammal having leukemia a therapeutically effective combination of an enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid and Ara-C (cytarabine), where the Ara-C is administered in a total amount of about 5-1500 mg/mper day for at least one day.