发明名称 |
COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS |
摘要 |
A compound is selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof. |
申请公布号 |
US2014065103(A1) |
申请公布日期 |
2014.03.06 |
申请号 |
US201313767347 |
申请日期 |
2013.02.14 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GREEN JEREMY;CHAN CHUN KONG LAVAL;DAS SANJOY KUMAR;POISSON CARL;NANTHAKUMAR SUGANTHINI;WAAL NATHAN;LI PAN;RONKIN STEVEN;LAUFFER DAVID J.;WILSON DEAN M. |
分类号 |
C07D417/12;A61K31/381;A61K31/422;A61K31/4245;A61K31/427;A61K31/4436;A61K31/4535;A61K31/497;A61K31/5377;A61K31/7056;A61K38/21;C07D333/40;C07D409/06;C07D409/12;C07D413/12 |
主分类号 |
C07D417/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|