| 摘要 |
<p>[Problem] To provide: a crystal of anagliptin, which has high purity, excellent stability, low hygroscopicity and a property of being dissolved in water extremely satisfactorily; and a method for producing the crystal of anagliptin. [Solution] A crystal of anagliptin, which has peaks at points located adjacent to diffraction angles, each of which is expressed in 2theta, of 9.8°, 17.4°, 18.6°, 25.3° and 25.8° and has substantially the same powder X-ray diffraction pattern as that illustrated in fig. 1. The crystal can be produced by reacting N-(2-amino-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide with (2S)-N-chloroacetyl- 2-cyanopyrrolidine in an organic solvent, then purifying the resultant product by column chromatography to produce an amorphous form of anagliptin, and then crystallizing the amorphous form of anagliptin from 2-propanol.</p> |
