Fusion proteins capable of regulating intracellular calcium ion level by light and uses thereof

摘要

The present invention relates to a method and a kit for reversibly inhibiting a protein function using light-induced nanocluster formation, and provides a fusion protein, wherein a light-induced heterodimerized protein is connected to the N-terminal or C-terminal of stromal interaction molecule 1 (STIM1) protein or to a cytosolic fraction cleaved from the N-terminal of the STIM1 protein to a transmembrane domain.