| 发明名称 |
PD-1, RECEPTOR OF B7-4 AND USE OF THE SAME |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a method to modulate immune response.SOLUTION: PD-1 polypeptide is identified as a receptor to B7-4. B7-4 can inhibit the activation of an immunocyte when it is bound to an inhibitory receptor on the immunocyte. Therefore, modulation of immune response is induced by modulating costimulatory or inhibitory signal in the immunocyte by providing an agent which modulates PD-1, B7-4 and interaction between B7-4 and PD-1. |
| 申请公布号 |
JP2014040419(A) |
申请公布日期 |
2014.03.06 |
| 申请号 |
JP20130172201 |
申请日期 |
2013.08.22 |
| 申请人 |
DANA FARBER CANCER INSTITUTE INC;GENETICS INST LLC |
发明人 |
WOOD CLIVE;FREEMANN GORDON J |
| 分类号 |
A61K45/00;G01N33/50;A61K38/00;A61K39/00;A61K39/395;A61K45/06;A61P1/16;A61P3/10;A61P9/00;A61P9/10;A61P15/06;A61P19/02;A61P21/04;A61P25/00;A61P25/28;A61P29/00;A61P31/06;A61P31/12;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P33/12;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P41/00;A61P43/00;C07K14/705;C07K16/28;C12N15/09;C12N15/12;C12Q1/02;G01N33/15;G01N33/566 |
主分类号 |
A61K45/00 |
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