PYRIDAZINONE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

摘要

The present invention is in the scope of the field of pharmaceutical chemistry. Specifically, the present invention relates to pyridazinone compounds of formula (I) or isomers, pharmaceutically acceptable salts, esters, prodrugs or solvates thereof, preparation method, pharmaceutical compositions thereof and use in manufacture of tyrosine kinase inhibitors, specially c-Met inhibitors. Said compounds or pharmaceutical compositions are used to prevent and/or treat tumor diseases related to c-Met abnormality as tyrosine kinase inhibitors, specially c-Met inhibitors.