DEVICES, SYSTEMS, AND METHODS FOR TREATING CIRCADIAN RHYTHM DISORDERS

摘要

A closed-loop therapy delivery system for treating a circadian rhythm disorder in a mammal can include: at least one electrode configured to deliver a therapy signal to an autonomic nervous system (ANS) nerve target associated with the circadian rhythm disorder; a power source in electrical communication with the at least one electrode; at least one sensor in electrical communication with the at least one electrode; and a controller in electrical communication with each of the at least one electrode and the at least one sensor. The controller can be configured to automatically coordinate operation of the power source. The controller can be configured to direct delivery of the therapy signal to the ANS nerve target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby treat the circadian rhythm disorder.