发明名称 |
RISPERIDONE SUSTAINED RELEASE MICROSPHERE COMPOSITION |
摘要 |
A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage. |
申请公布号 |
EP2701687(A1) |
申请公布日期 |
2014.03.05 |
申请号 |
EP20120777430 |
申请日期 |
2012.04.10 |
申请人 |
SHANDONG LUYE PHARMACEUTICAL CO., LTD. |
发明人 |
SUN, KAOXIANG;LIANG, RONGCAI;WANG, QILIN;WANG, WENYAN;LIU, WANHUI;LI, YOUXIN |
分类号 |
A61K9/16;A61K9/14;A61K9/19;A61K31/519;A61K47/34;A61P25/18 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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