发明名称 |
Truncated fragments of alpha-synuclein in lewy body disease |
摘要 |
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals. |
申请公布号 |
EP2272539(B1) |
申请公布日期 |
2014.03.05 |
申请号 |
EP20100006457 |
申请日期 |
2005.10.19 |
申请人 |
ELAN PHARMACEUTICALS, LLC |
发明人 |
CHILCOTE, TAMIE J.;GOLDSTEIN, JASON;ANDERSON, JOHN P.;WALKER, DONALD |
分类号 |
G01N33/68;A01K67/027;A61K38/00;A61K49/00;C07K16/18;C12N15/85 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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