发明名称 |
PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF |
摘要 |
<p>(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR±-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR±-positive cells.</p> |
申请公布号 |
EP2703487(A1) |
申请公布日期 |
2014.03.05 |
申请号 |
EP20120777041 |
申请日期 |
2012.04.03 |
申请人 |
GENOMIX CO., LTD.;OSAKA UNIVERSITY |
发明人 |
TAMAI, KATSUTO;YAMAZAKI, TAKEHIKO;KANEZAKI, TSUTOMU;SAKURAI, SHIGERU;NOGUCHI, YUKIKO;ENDO, MAYUMI;HAMABUCHI, NATSUMI;NAITO, KANA |
分类号 |
C12N15/09;A61K31/711;A61K31/713;A61K35/12;A61K35/28;A61K35/76;A61K38/00;A61K48/00;A61P1/00;A61P1/04;A61P9/00;A61P9/10;A61P17/00;A61P19/00;A61P21/00;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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