发明名称 |
Conjungated factor VIII molecules |
摘要 |
The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compositions comprising said Factor VIII molecules. |
申请公布号 |
EP2626079(A3) |
申请公布日期 |
2014.03.05 |
申请号 |
EP20130150933 |
申请日期 |
2009.02.26 |
申请人 |
NOVO NORDISK A/S |
发明人 |
DEFRESS, SHAWN;VANDAHL, BRIAN BERG STIDSEN;BOLT, GERT;STENNICKE, HENNING RALF;THIM, LARS;STEENSTRUP, THOMAS DOCK |
分类号 |
A61K38/37;A61K47/48;A61P7/04;C07K14/755 |
主分类号 |
A61K38/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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