发明名称 |
AN EXPEDITIOUS SYNTHESIS OF UBIQUITINATED PEPTIDE CONJUGATES |
摘要 |
The present invention discloses a process for preparing ubiquinated peptide conjugates comprising a ubiquitin peptide residue UR attached at its C-terminus to a substrate peptide via a native isopeptide bond, this process comprising combining Native Chemical Ligation (NCL) and solid phase peptide synthesis (SPPS). Further are disclosed ubiquinated peptide conjugates containing a native isopeptide bond, as well as various uses thereof. |
申请公布号 |
EP2575849(A4) |
申请公布日期 |
2014.03.05 |
申请号 |
EP20110789349 |
申请日期 |
2011.06.01 |
申请人 |
BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY |
发明人 |
BRIK, ASHRAF;KUMAR, AJISH;ERLICH, LESLIE;SPASSER, LIAT |
分类号 |
A61K38/00;C07K5/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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