| 摘要 |
For enhancing the migration of terbinafine hydrochloride to the horny layer, it is advantageous to dissolve and incorporate the hydrochloride as the molecular type (nondissociable type). However, it has been difficult to dissolve and incorporate terbinafine hydrochloride as the molecular type because the solubility of terbinafine hydrochloride in neutral to alkaline pharmaceutical preparations is extremely low. The antifungal agent composition for external use comprises terbinafine hydrochloride, a polyol, and a lower alcohol, has a pH in a neutral to alkaline range, and is clear. It is a terbinafine hydrochloride-containing antifungal agent for external use which is excellent in the property of migrating to the horny layer. |
