STRATIFYING PATIENT POPULATIONS THROUGH CHARACTERIZATION OF DISEASE-DRIVING SIGNALING
摘要
<p>A method of stratifying a set of disease-exhibiting patients prior to clinical trial of a target therapy begins by using a molecular footprint derived from a knowledgebase and other patient data to identify genes that are differentially expressed in a direction consistent with increase in the target activity. Therapeutic target "signaling strength" in individual patients of the set is then assessed using the genes identified and a strength algorithm. Based on their therapeutic target signaling strength, the set of disease-exhibiting patients are then stratified along a continuum. One or more gene expressions or other biomarkers may be specified for use in categorizing other disease-exhibiting patient populations. Alternative therapeutic targets are analyzed with respect to the likely non-responders, as evidenced by their differential signaling strength.</p>
申请公布号
EP2701579(A2)
申请公布日期
2014.03.05
申请号
EP20120776199
申请日期
2012.04.26
申请人
SELVENTA INC.
发明人
CATLETT, NATALIE, ANNE LEECH;DRUBIN, DAVID, ALAN;ELLISTON, KEITH, OWEN;KENNEY, RENEE, MARIE DEEHAN;MACORITTO, MICHAEL, PAUL