CHEMICAL MODIFICATION OF APOLIPOPROTEIN MIMETIC PEPTIDES FOR THE PRODUCTION OF THERAPEUTIC AGENTS
摘要
<p>Hydrocarbon stapling of apolipoprotein mimetic peptides increases the helicity of the peptides, enhances their ability to promote cholesterol efflux by multiple mechanisms and makes them resistant to proteolysis. Hydrocarbon stapled amphipathic helical peptides are useful in the treatment of cardiovascular diseases and other disorders.</p>
申请公布号
EP2701725(A1)
申请公布日期
2014.03.05
申请号
EP20120726266
申请日期
2012.04.30
申请人
KINEMED, INC.;UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
REMALEY, ALAN, T.;AMAR, MARCELO;SVIRIDOV, DENIS;IKPOT, IMOH, Z.;OSEI-HWEDIEH, DAVID;TURNER, SCOTT