发明名称 |
Structure of the C-terminal region of the insulin receptor alpha-chain and of the insulin-like growth factor receptor alpha-chain |
摘要 |
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR alpha-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R. |
申请公布号 |
US8666718(B2) |
申请公布日期 |
2014.03.04 |
申请号 |
US201013265879 |
申请日期 |
2010.03.09 |
申请人 |
LAWRENCE MICHAEL COLIN;SMITH BRIAN JOHN;MENTING JOHN GERBRANDT TASMAN;WARD COLIN WESLEY;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
LAWRENCE MICHAEL COLIN;SMITH BRIAN JOHN;MENTING JOHN GERBRANDT TASMAN;WARD COLIN WESLEY |
分类号 |
G01N33/48;G06G7/58 |
主分类号 |
G01N33/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|