| 摘要 |
The invention pertains to controlled release excipient composition suitable in formulation of a slow release tablet, wherein the composition contains a synergistic mixture of substantially uncrosslinked carboxymethyl starch, or sodium starch glycolate (SSG), and a hydrophilic, non-ionic cellulose ether, preferably hydroxypropylmethylcellulose. Whether or not a SSG in the mixture is sufficiently uncrosslinked in the context of the invention can be determined by means of sedimentation: 0.25 g of the formulation in 100 ml deionized water after 24 hours at 25 °C, if subjected to centrifugation at 6080 G at 25 °C for 15 minutes, should exhibit a sedimentation volume of more than 60 ml. |
