发明名称 |
Methods using recombinant anti-epidermal growth factor receptor antibody compositions |
摘要 |
The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides the use of an antibody composition with two distinct non-overlapping binding specificities to human EGFR. The antibody composition is effecting in treating cancer following treatment with other anti-EGFR antibodies, whether the cancer shows progression during or following the prior treatment or not. The antibody composition can also be used for repeated treatment of recurrent tumors following first-line therapy with the antibody composition of the invention, as the composition does not lead to selection of resistant tumors. A further therapeutic use is the use of an antibody composition of the invention for treatment of cancer that is resistant to known anti-EGFR antibodies. |
申请公布号 |
US8663640(B2) |
申请公布日期 |
2014.03.04 |
申请号 |
US200913061417 |
申请日期 |
2009.08.27 |
申请人 |
PEDERSEN MIKKEL WANDAHL;KRAGH MICHAEL;HEY ADAM S.;JACOBSEN HELLE;SYMPHOGEN A/S |
发明人 |
PEDERSEN MIKKEL WANDAHL;KRAGH MICHAEL;HEY ADAM S.;JACOBSEN HELLE |
分类号 |
A61K39/395;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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