发明名称 |
siRNA compositions and methods for potently inhibiting viral infection |
摘要 |
No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of beta-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. |
申请公布号 |
US8664188(B2) |
申请公布日期 |
2014.03.04 |
申请号 |
US20090636234 |
申请日期 |
2009.12.11 |
申请人 |
ZHENG BOJIAN;SUI HONGYAN;LIN YONGPING;XIANGXUE GROUP (HONG KONG) COMPANY LIMITED |
发明人 |
ZHENG BOJIAN;SUI HONGYAN;LIN YONGPING |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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