发明名称 |
Fremgangsmåde til fremstilling af chloriner og deres farmaceutiske anvendelser |
摘要 |
The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalities that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging. |
申请公布号 |
DK2346874(T3) |
申请公布日期 |
2014.03.03 |
申请号 |
DK20090768255T |
申请日期 |
2009.10.22 |
申请人 |
UNIVERSIDADE DE COIMBRA;BLUEPHARMA - INDUSTRIA FARMACEUTICA, S.A. |
发明人 |
STOCHEL, GRAZYNIA;DA SILVA ARNAUT MOREIRA, LUAS GUILHERME;MIGUENS PEREIRA, MARIA;FORMOSINHO SANCHES SIMA¿ES, SEBASTIA£O JOSE;MAGALHA¿ES SIMA¿ES, SERGIO PAULO;URBANSKA, KRYSTYNA |
分类号 |
C07D487/22;A61K31/409;A61P35/00 |
主分类号 |
C07D487/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|