发明名称 |
PEPTIDE BIFONCTIONNEL |
摘要 |
<p>The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.</p> |
申请公布号 |
FR2986233(B1) |
申请公布日期 |
2014.02.28 |
申请号 |
FR20120050932 |
申请日期 |
2012.02.01 |
申请人 |
REGENTIS INTERNATIONAL;UNIVERSITE DE REIMS CHAMPAGNE ARDENNE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
HORNEBECK WILLIAM;ATTIA JOAN;LORIMIER SANDRINE;ANTONICELLI FRANCK |
分类号 |
C07K14/435;A61K8/64;A61K38/17;A61P17/02;A61Q19/08;C07K19/00 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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