发明名称 |
ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF |
摘要 |
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. |
申请公布号 |
KR20140024395(A) |
申请公布日期 |
2014.02.28 |
申请号 |
KR20137030816 |
申请日期 |
2012.04.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SCHAFFER DAVID V.;KLIMCZAK RYAN R.;KOERBER JAMES T.;PLANNERY JOHN G.;DALKARA MOUROT DENIZ;VISEL MEIKE;BYRNE LEAH C.T. |
分类号 |
C12N7/01;A61K48/00;C12N15/864 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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