Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid

摘要

598085 Disclosed is are substituted 1,3-propanedisulfonate compounds of formula (II) where the substituents are as disclosed in the specification. Also disclosed are pharmaceutical compositions comprising a compound of formula (II), the method of preparing a compound of formula (II) and the use of a compound of formula (II) in the manufacture of a medicament. The medicament is useful in the treatment of amyloid A amyloidosis, delaying progression of a renal disorder, treating diabetes mellitus is type 1 or type 2 diabetes by increasing insulin levels in the blood.