| 摘要 |
<p>The present invention relates to a method for treating insulin resistance, neuronal loss associated with stroke, ischemia, central nervous system trauma, a central nervous system disorder, a neurodegenerative disease, the adverse consequences of the over-stimulation of excitatory amino acids, a psychiatric disease, epilepsy or other convulsive disorder, chronic pain, CMV retinitis, urinary incontinence, or for inducing anesthesia; which comprises administering to an animal or human in need thereof an effective amount of a pharmaceutical formulation comprising an effective amount of a pyrone-indole derivative of formula (I): Ar—B—Ar′ (I) wherein Ar represents an indole nucleus ring system: Ar′represents an alpha-, beta- or gamma-pyrone nucleus ring system: and each of B, R1-4, and R1-2′are one of the groups as defined herein.</p> |
