COMBINED SOFT DOSAGE FORM FOR LOCAL TREATMENT OF PERIODONTICS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutics and represents a combined drug preparation for the local treatment of periodontics, including a complex of metronidazole and chlorhexidine in a combination with sodium fusidine, sweetening agents and a pharmaceutically acceptable gel base in the following proportions, g: sodium fusidine 1.8-2.2; metronidazole 0.9-1.1; chlorhexidine bigluconate (in the form of 20% chlorhexidine bigluconate) 0.42-0.58 in the amount equivalent to chlorhexidine 0.08-0.12; sodium saccharinate 0.1-0.3; monoammonium glycerrhizinate (MM100) 0.006-0.008; aerosil 200 (colloidal silicon dioxide) 5.5-6.0; paraffin oil (Vaselin oil) - the rest up to 100 g.EFFECT: invention provides creating the therapeutic pharmaceutical composition in the form of gel possessing the antibacterial and anti-inflammatory action with an optimum combination of the ingredients to provide a stable depot of the active substances within an area of inflammation for the purpose of treating infectious-inflammatory periodontics of various aetiologies.3 ex, 1 tbl