Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
摘要
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
申请公布号
AU2009233951(B2)
申请公布日期
2014.02.27
申请号
AU20090233951
申请日期
2009.04.06
申请人
AMGEN INC.
发明人
MCGEE, LAWRENCE R.;FAN, PINGCHEN;FU, JIASHENG;LI, ZHIHONG;DAI, KANG;SHARMA, RAJIV;LI, KEXUE;FISHER, BENJAMIN;EKSTEROWICZ, JOHN;WANG, XIAODONG;CONNORS, RICHARD V.
