发明名称 |
COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS |
摘要 |
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. |
申请公布号 |
WO2014029983(A1) |
申请公布日期 |
2014.02.27 |
申请号 |
WO2013GB52192 |
申请日期 |
2013.08.20 |
申请人 |
ARDELYX, INC.;ASTRAZENECA UK LIMITED |
发明人 |
LEADBETTER, MICHAEL;BELL, NOAH;LEWIS, JASON;JACOBS, JEFFREY;CARRERAS, CHRISTOPHER |
分类号 |
A61K47/48;A61P1/00;A61P9/04;A61P9/12;A61P13/12 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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