发明名称 DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION.
摘要 <p>Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The didpeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the didpetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.</p>
申请公布号 MX2013005413(A) 申请公布日期 2014.02.27
申请号 MX20130005413 申请日期 2011.11.15
申请人 RAMOT AT TEL-AVIV UNIVERSITY LTD. 发明人 ULRICH ABEL;EHUD GAZIT;YANIV AMIR;LUDMILA BUZHANSKY;ANAT FRYDMAN-MAROM
分类号 C07K5/06;A61P25/28 主分类号 C07K5/06
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