摘要 |
The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. |
申请人 |
MERCK SHARP & DOHME CORP.;APGAR, JAMES, M.;ARASAPPAN, ASHOK;BIFTU, TESFAYE;CHEN, PING;FENG, DANQING;GUIDRY, ERIN;HICKS, JACQUELINE, D.;KEKEC, AHMET;LEAVITT, KENNETH, J.;LI, BING;SEBHAT, IYASSU;QIAN, XIAOXIA;WEI, LAN;WILKENING, ROBERT, R.;WU, ZHICAI |
发明人 |
APGAR, JAMES, M.;ARASAPPAN, ASHOK;BIFTU, TESFAYE;CHEN, PING;FENG, DANQING;GUIDRY, ERIN;HICKS, JACQUELINE, D.;KEKEC, AHMET;LEAVITT, KENNETH, J.;LI, BING;SEBHAT, IYASSU;QIAN, XIAOXIA;WEI, LAN;WILKENING, ROBERT, R.;WU, ZHICAI |