发明名称 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS.
摘要 The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
申请公布号 MX2014000831(A) 申请公布日期 2014.02.27
申请号 MX20140000831 申请日期 2012.08.06
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 DONALD J. PINTO;JAMES R. CORTE;PAUL J. GILLIGAN;TIANAN FANG;LEON M. SMITH II;YUFENG WANG;WU YANG;WILLIAM R. EWING
分类号 C07D487/08;A61K31/395 主分类号 C07D487/08
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