发明名称 |
RAMAN, INFRARED, OR RAMAN-INFRARED ANALYSIS OF PERIPHERAL BLOOD PLASMA PROTEIN STRUCTURE AND ITS RELATION TO COGNITIVE DEVELOPMENT IN ALZHEIMER'S DISEASE |
摘要 |
<p>The present invention relates to a Raman spectroscopy method for determining protein structure associated with global cognitive deterioration in Alzheimer's disease from the Raman spectroscopic analysis of a human blood sample, preferably of a human blood plasma sample, comprising obtaining at least one spectral value of at least one of the Raman spectrum regions comprised between 16001700 cm-1, between 910980 cm-1, between 730760 cm-1 and/or between 390450 cm-1, and where said spectral value allows obtaining an indication of the presence or absence of protein structure associated with a condition of Alzheimer's disease. The present invention also relates to a method for the infrared spectroscopic analysis of a blood sample, by means of additionally obtaining at least one spectral value of at least one of the infrared spectrum regions comprised between 1600 and 1700 cm-1, and/or between 1000 and 1150 cm-1 and/or between 1140 and 1190 cm-1 Optionally, the Raman spectroscopy method further comprises the infrared spectroscopic analysis of the same blood sample. The invention also relates to a diagnostic method for diagnosing Alzheimer's disease comprising measuring a Raman spectrum and/or an infrared spectrum of a plasma sample.</p> |
申请公布号 |
CA2882673(A1) |
申请公布日期 |
2014.02.27 |
申请号 |
CA20132882673 |
申请日期 |
2013.08.20 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS C.S.I.C.;FUNDACION INVESTIGACION BIOMEDICA HOSPITAL UNIVERSITARIO 12 DE OCTUBRE;INSTITUTO DE SALUD CARLOS III;FUNDACION CIEN;UNIVERSIDAD COMPLUTENSE DE MADRID |
发明人 |
CARMONA HERNANDEZ, PEDRO;TOLEDANO GASCA, ADOLFO;CALERO LARA, MIGUEL;MARTINEZ MARTIN, PABLO;BERMEJO PAREJA, FELIX;MOLINA SANTOS, MARINA |
分类号 |
G01N21/35;G01N21/65 |
主分类号 |
G01N21/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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