| 摘要 |
This invention pertains to the preparation of arrays containing the proteome of wheat, including gluten and non-gluten proteins. Antibodies to wheat gluten have been shown to be elevated, not only in celiac disease and wheat allergy, but also in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism. The array would be able to detect specific patterns of antibody reactivity to gluten proteins that are unique to each disease and which may have utility as biomarkers. The array may also have use in detecting patterns of cross-reactive autoantibodies in other disorders. |
